PROFESSIONAL INFORMATION

Scheduling status S0

 

1.    Name of medicine
Tala Health & Wellness  
MEGA BRAIN HEALTH

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2.    Qualitative and Quantitative Composition 
Each capsule contains 500 mg nicotinamide 
See 6.1 for full list of ingredients

 

3.    Pharmaceutical form
White capsules 
 
4.    Clinical Particulars 
4.1 Therapeutic Indications 
•    Helps to metabolise carbohydrates, fats, and proteins
•    Contributes to normal growth and development
•    A factor in the maintenance of good health 
Nicotinamide is converted into nicotinamide adenine dinucleotide (NAD) on a cellular level. NAD is a coenzyme that is a hydrogen carrier in metabolic reactions, especially in tissue respiration. Restoring low levels of NAD helps prevent cognitive decline

 

4.2 Posology and method of administration 
Adults: Take one capsule daily with food

Elderly populations
No studies have been performed in elderly populations, but no dose adjustment is expected to be required. 
 
Paediatric populations: 
Not recommended for use in children and adolescents.

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4.3 Contraindications: 
Do not take MEGA BRAIN HEALTH if you are allergic to large doses of nicotinamide.  

Special warnings and precautions for use

 

None Known 

Interactions with other medicines and other forms of interaction
Risk of myopathy and rhabdomyolysis were reported in a review of patients on statins.
There is an increased risk for thrombocytopenia in haemodialysis patients.  

Fertility, pregnancy, and lactation 
Safety of MEGA BRAIN HEALTH in pregnancy and lactation has not been established. 
Consult a physician prior to use if you are pregnant or breastfeeding

Undesirable effects   
Nicotinamide is mostly well tolerated. Possible side effects include nausea, vomiting, and other gastrointestinal symptoms as well as headache, fatigue, and dizziness. 
Liver toxicity is associated with high doses of nicotinamide
Emergency treatment should be sought if an allergic reaction is suspected 

Overdose
Symptoms such as nausea, vomiting, flatulence, headache, fatigue, and dizziness. 
Liver toxicity is associated with high doses of nicotinamide

5.    Pharmacological properties 

Chemically, nicotinamide forms part of the coenzymes nicotinamide adenine dinucleotide (NAD), used in oxidation-reduction reactions in the body. NAD is also thought to be a signalling molecule controlling a number of processes such as energy metabolism and cell survival. 

Pharmaceutical properties 
List of excipients
Filler, magnesium stearate

Incompatibilities
In the absence of studies MEGA BRAIN HEALTH should not be given with other medicines 

Shelf Life
24 months

Special precautions for storage
Keep out of reach of children. 
Store at or below 25 ˚C

Presentation
Amber glass bottle containing 30 capsules 

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6.    Business address: 
454 Koedoesnek Avenue
Waterkloof Ridge
012 347 8497

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7.    Date of revision of the text
February 2024

References:
1.    Jared M. Campbell: Supplementation with NAD+ and Its Precursors to Prevent
Cognitive Decline across Disease Contexts. Nutrients 2022, 14, 3231.
2.    Luis Rajman, Karolina Chwalek, and David A. Sinclair: Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018 March 06; 27(3): 529–547.
3.    Stephen I. Winter, James I. Boyer: Hepatic Toxicity from large doses of Vitamin B (Nicotinamide). NEJM Dec (1973) 1180
4.    Hadeler EK, Maderal AD. Drug interactions of natural supplements in dermatology: a review. Int J Dermatol. 2021 Oct;60(10):1183-1189